Complement activation and inhibition: a delicate balance.

@article{Sjberg2009ComplementAA,
  title={Complement activation and inhibition: a delicate balance.},
  author={Andreas P. Sj{\"o}berg and Leendert A Trouw and Anna M. Blom},
  journal={Trends in immunology},
  year={2009},
  volume={30 2},
  pages={
          83-90
        }
}
Complement is part of the innate immune defence and not only recognizes microbes but also unwanted host molecules to enhance phagocytosis and clearance. This process of opsonisation must be tightly regulated to prevent immunopathology. Endogenous ligands such as dying cells, extracellular matrix proteins, pentraxins, amyloid deposits, prions and DNA, all bind the complement activator C1q, but also interact with complement inhibitors C4b-binding protein and factor H. This contrasts to the… CONTINUE READING
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