Complement activating antibodies to myelin oligodendrocyte glycoprotein in neuromyelitis optica and related disorders

@inproceedings{Mader2011ComplementAA,
  title={Complement activating antibodies to myelin oligodendrocyte glycoprotein in neuromyelitis optica and related disorders},
  author={Simone Mader and Viktoria Gredler and Kathrin Schanda and Kevin Rost{\'a}sy and Irena Dujmovic and Kristian Pfaller and Andreas Lutterotti and Sven Jarius and Franziska Di Pauli and Bettina Kuenz and Rainer Ehling and Harald Hegen and Florian Deisenhammer and Fahmy Aboul-Enein and Maria K. Storch and Peter Koson and Jelena S. Drulovi{\'c} and Wolfgang Kristoferitsch and Thomas F H Berger and Markus Reindl},
  booktitle={Journal of Neuroinflammation},
  year={2011}
}
Serum autoantibodies against the water channel aquaporin-4 (AQP4) are important diagnostic biomarkers and pathogenic factors for neuromyelitis optica (NMO). However, AQP4-IgG are absent in 5-40% of all NMO patients and the target of the autoimmune response in these patients is unknown. Since recent studies indicate that autoimmune responses to myelin oligodendrocyte glycoprotein (MOG) can induce an NMO-like disease in experimental animal models, we speculate that MOG might be an autoantigen in… CONTINUE READING
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