Complement System Part II: Role in Immunity

  title={Complement System Part II: Role in Immunity},
  author={Nicolas S. Merle and Remi Noe and Lise Halbwachs-Mecarelli and V{\'e}ronique Fr{\'e}meaux-Bacchi and Lubka T Roumenina},
  booktitle={Front. Immunol.},
The complement system has been considered for a long time as a simple lytic cascade, aimed to kill bacteria infecting the host organism. Nowadays, this vision has changed and it is well accepted that complement is a complex innate immune surveillance system, playing a key role in host homeostasis, inflammation, and in the defense against pathogens. This review discusses recent advances in the understanding of the role of complement in physiology and pathology. It starts with a description of… CONTINUE READING
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