Complement Polymorphisms in Kidney Transplantation: Critical in Graft Rejection?

@article{Michielsen2017ComplementPI,
  title={Complement Polymorphisms in Kidney Transplantation: Critical in Graft Rejection?},
  author={Laura A. Michielsen and Arjan D. van Zuilen and Ivo S. Muskens and Marianne C Verhaar and Henny G Otten},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2017},
  volume={17 8},
  pages={
          2000-2007
        }
}
The complement system, as part of the innate immune system, plays an important role in renal transplantation. Complement is involved in the protection against foreign organisms and clearance of apoptotic cells but can also cause injury to the renal allograft, for instance, via antibody binding or in ischemia-reperfusion injury. Numerous polymorphisms in complement factors have been identified thus far; some of them result in different functionalities or alter complement levels. In this review… CONTINUE READING
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