Complement Inhibition With Soluble Complement Receptor Type 1 in Cardiopulmonary Bypass

@article{Gillinov1993ComplementIW,
  title={Complement Inhibition With Soluble Complement Receptor Type 1 in Cardiopulmonary Bypass},
  author={Alan Marc Gillinov and Patrick A. Devaleria and Jerry A. Winkelstein and Ian C. Wilson and William E. Curtis and Darcy Shaw and C Grace Yeh and Alfred R. Rudolph and William A. Baumgartner and Ahvie Herskowitz},
  journal={The Annals of thoracic surgery},
  year={1993},
  volume={55 3},
  pages={
          619-24
        }
}
Although complement activation during cardiopulmonary bypass (CPB) is well documented, its pathogenic role in postperfusion organ injury is unproven. In this study, soluble human complement receptor type 1 (sCR1), a potent inhibitor of complement activation, was used to determine the contribution of complement activation to pulmonary injury in a porcine model of CPB. In vitro experiments demonstrated that sCR1 inhibits both classic and alternative complement pathways in the pig. Seven control… CONTINUE READING
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