Complement Factor H and Simian Virus 40 bind the GM1 ganglioside in distinct conformations.

Abstract

Mammalian cell surfaces are decorated with a variety of glycan chains that orchestrate development and defense and are exploited by pathogens for cellular attachment and entry. While glycosidic linkages are, in principle, flexible, the conformational space that a given glycan can sample is subject to spatial and electrostatic restrictions imposed by its… (More)
DOI: 10.1093/glycob/cwv170

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