Complement Factor H Polymorphism and Age-Related Macular Degeneration

@article{Edwards2005ComplementFH,
  title={Complement Factor H Polymorphism and Age-Related Macular Degeneration},
  author={Albert O. Edwards and Robert Ritter and Kenneth J. Abel and A. Manning and Carolien I. M. Panhuysen and Lindsay A. Farrer},
  journal={Science},
  year={2005},
  volume={308},
  pages={421 - 424}
}
Age-related macular degeneration (AMD) is a common, late-onset, and complex trait with multiple risk factors. Concentrating on a region harboring a locus for AMD on 1q25-31, the ARMD1 locus, we tested single-nucleotide polymorphisms for association with AMD in two independent case-control populations. Significant association (P = 4.95 × 10-10) was identified within the regulation of complement activation locus and was centered over a tyrosine-402 → histidine-402 protein polymorphism in the gene… Expand

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