Complement Factor H Binds to Human Serum Apolipoprotein E and Mediates Complement Regulation on High Density Lipoprotein Particles.

@article{Haapasalo2015ComplementFH,
  title={Complement Factor H Binds to Human Serum Apolipoprotein E and Mediates Complement Regulation on High Density Lipoprotein Particles.},
  author={Karita Haapasalo and Kok P. M. van Kessel and Eija Nissil{\"a} and Jari Metso and Tiira Johansson and Sini Miettinen and Markku Varjosalo and Juha Kirveskari and Pentti I Kuusela and Angelika Chroni and Matti S Jauhiainen and Jos A G van Strijp and T Sakari Jokiranta},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 48},
  pages={28977-87}
}
The alternative pathway of complement is an important part of the innate immunity response against foreign particles invading the human body. To avoid damage to host cells, it needs to be efficiently down-regulated by plasma factor H (FH) as exemplified by various diseases caused by mutations in its domains 19-20 (FH19-20) and 5-7 (FH5-7). These regions are also the main interaction sites for microbial pathogens that bind host FH to evade complement attack. We previously showed that inhibition… CONTINUE READING
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