Complement C5a receptors in the pituitary gland: expression and function.

@article{Francis2008ComplementCR,
  title={Complement C5a receptors in the pituitary gland: expression and function.},
  author={Karen M. Francis and Bryan M Lewis and Peter N Monk and Jack Ham},
  journal={The Journal of endocrinology},
  year={2008},
  volume={199 3},
  pages={417-24}
}
Communication between the immune and endocrine system is important for the control of inflammation that is primarily mediated through the hypothalamic-pituitary-adrenal axis. The innate immune system rapidly responds to pathogens by releasing complement proteins that include the anaphylatoxins C3a and C5a. We previously reported the existence of C3a receptors in the anterior pituitary gland and now describe the presence of C5a receptors in the gland. C5a and its less active derivative (C5adR… CONTINUE READING