Complement C5a activation of phospholipase D in human neutrophils. A major route to the production of phosphatidates and diglycerides.

@article{Mullmann1990ComplementCA,
  title={Complement C5a activation of phospholipase D in human neutrophils. A major route to the production of phosphatidates and diglycerides.},
  author={T J Mullmann and Marvin Siegel and Robert W. Egan and M. Motasilm Billah},
  journal={Journal of immunology},
  year={1990},
  volume={144 5},
  pages={1901-8}
}
The contribution of phospholipase D (PLD) to the production of phosphatidic acid (PA) and diglyceride (DG) by C5a-stimulated human neutrophils has been studied. Membrane-associated 1-O-alkyl-phosphatidylcholine (alkyl-PC) was double labeled with 3H and 32P by incubating neutrophils with [3H]alkyl-lysoPC and alkyl-[32P]lysoPC. Upon stimulation with… CONTINUE READING