Complement C3 plays an essential role in the control of opportunistic fungal infections.

@article{Tsoni2009ComplementCP,
  title={Complement C3 plays an essential role in the control of opportunistic fungal infections.},
  author={Stavroula V Tsoni and Ann M. Kerrigan and Mohlopheni J Marakalala and Naren Srinivasan and Maureen S Duffield and Philip R Taylor and Marina Botto and Chad Steele and Gordon D. Brown},
  journal={Infection and immunity},
  year={2009},
  volume={77 9},
  pages={
          3679-85
        }
}
The innate recognition of fungal pathogens is a crucial first step in the induction of protective antifungal immunity. Complement is thought to be one key component in this process, facilitating fungal recognition and inducing early inflammation. However, the roles of the individual complement components have not been examined extensively. Here we have used mice lacking C3 to examine its role in immunity to opportunistic fungal pathogens and show that this complement component is essential for… CONTINUE READING

Similar Papers

Figures and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 33 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 32 REFERENCES

Activation of the complement system by pathogenic fungi.

  • Clinical microbiology reviews
  • 1996
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Molecular organization and function of the complement system.

  • Annual review of biochemistry
  • 1988
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL