Complement C3 deficiency: human, animal, and experimental models.

  title={Complement C3 deficiency: human, animal, and experimental models.},
  author={Leon Singer and Harvey R. Colten and Rick A Wetsel},
  journal={Pathobiology : journal of immunopathology, molecular and cellular biology},
  volume={62 1},
The third complement component (C3) is a multifunctional glycoprotein that interacts with numerous serum proteins, cell surface receptors, and membrane-associated regulatory proteins. Deficiencies of C3 have been reported in several human kindred of different ethnic backgrounds and from different geographic regions. In addition, inherited C3 deficiency has been discovered in certain strains of guinea pigs, dogs, and rabbits, and has been experimentally induced in animals by injections of cobra… CONTINUE READING
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