Complement C3 Drives Autophagy-Dependent Restriction of Cyto-invasive Bacteria.

  title={Complement C3 Drives Autophagy-Dependent Restriction of Cyto-invasive Bacteria.},
  author={Matthew T. Sorbara and Elisabeth G. Foerster and Jessica Tsalikis and Mena Abdel-Nour and Joseph Mangiapane and Imogen Sirluck-Schroeder and Ivan Tattoli and Rob van Dalen and David E. Isenman and John R. Rohde and Stephen E. Girardin and Dana J Philpott},
  journal={Cell host & microbe},
  volume={23 5},
In physiological settings, the complement protein C3 is deposited on all bacteria, including invasive pathogens. However, because experimental host-bacteria systems typically use decomplemented serum to avoid the lytic action of complement, the impact of C3 coating on epithelial cell responses to invasive bacteria remains unexplored. Here, we demonstrate that following invasion, intracellular C3-positive Listeria monocytogenes is targeted by autophagy through a direct C3/ATG16L1 interaction… CONTINUE READING
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