Complement C2 receptor inhibitor trispanning confers an increased ability to resist complement-mediated lysis in Trypanosoma cruzi.

@article{Cestari2008ComplementCR,
  title={Complement C2 receptor inhibitor trispanning confers an increased ability to resist complement-mediated lysis in Trypanosoma cruzi.},
  author={Igor dos S Cestari and Ingrid Evans-Osses and Juliana C Freitas and Jameel M Inal and Marcel I. Ramirez},
  journal={The Journal of infectious diseases},
  year={2008},
  volume={198 9},
  pages={1276-83}
}
The ability to resist complement differs between the Y and Colombiana Trypanosoma cruzi strains. We found that the Y strain of T. cruzi was more able to resist the classical and lectin pathways of complement activation than the Colombiana strain. The complement C2 receptor inhibitor trispanning gene (CRIT) is highly conserved in both strains. At the protein level, CRIT is expressed only in stationary-phase epimastigotes of the Y but not the Colombiana strain and is expressed in infectious… CONTINUE READING