Complement C1q reduces early atherosclerosis in low-density lipoprotein receptor-deficient mice.

@article{Bhatia2007ComplementCR,
  title={Complement C1q reduces early atherosclerosis in low-density lipoprotein receptor-deficient mice.},
  author={Vinay K Bhatia and Sheng Bu Yun and Viola W. Y. Leung and David C. Grimsditch and Gregory Martin Benson and Marina B Botto and Joseph J Boyle and Dorian O. Haskard},
  journal={The American journal of pathology},
  year={2007},
  volume={170 1},
  pages={
          416-26
        }
}
We explored the role of the classic complement pathway in atherogenesis by intercrossing C1q-deficient mice (C1qa-/-) with low-density lipoprotein receptor knockout mice (Ldlr-/-). Mice were fed a normal rodent diet until 22 weeks of age. Aortic root lesions were threefold larger in C1qa-/-/Ldlr-/- mice compared with Ldlr-/- mice (3.72 +/- 1.0% aortic root versus 1.1 +/- 0.4%; mean +/- SEM, P < 0.001). Furthermore, the cellular composition of lesions in C1qa-/-/Ldlr-/- was more complex, with an… CONTINUE READING
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