Complement (C1q) fixing solid-phase screening for HLA antibodies increases the availability of compatible platelet components for refractory patients.

Abstract

BACKGROUND Immune refractoriness to platelet (PLT) transfusion is primarily due to HLA antibody. Patients at our institution are identified as refractory due to HLA by a Luminex-based immunoglobulin (Ig)G-single-antigen-bead (SAB) assay, but in highly sensitized patients, antigen-negative compatible donors cannot be found due to the high sensitivity of the… (More)
DOI: 10.1111/j.1537-2995.2011.03194.x

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@article{Fontaine2011ComplementF, title={Complement (C1q) fixing solid-phase screening for HLA antibodies increases the availability of compatible platelet components for refractory patients.}, author={Magali J Fontaine and Jenny Kuo and Ge Chen and Susan A. Galel and Evelyn C. Miller and Flavia Sequeira and Maurene K. Viele and Lawrence Tim Goodnough and Dolly B. Tyan}, journal={Transfusion}, year={2011}, volume={51 12}, pages={2611-8} }