Complement: a novel factor in basal and ischemia-induced neurogenesis.

@article{Rahpeymai2006ComplementAN,
  title={Complement: a novel factor in basal and ischemia-induced neurogenesis.},
  author={Yalda Rahpeymai and Max Albert Hietala and Ulrika Wilhelmsson and Andrew P. Fotheringham and Ioan Davies and A Nilsson and Joerg Zwirner and Rick A Wetsel and Craig Gerard and Milos Pekny and Marcela Pekna},
  journal={The EMBO journal},
  year={2006},
  volume={25 6},
  pages={
          1364-74
        }
}
Through its involvement in inflammation, opsonization, and cytolysis, the complement protects against infectious agents. Although most of the complement proteins are synthesized in the central nervous system (CNS), the role of the complement system in the normal or ischemic CNS remains unclear. Here we demonstrate for the first time that neural progenitor cells and immature neurons express receptors for complement fragments C3a and C5a (C3a receptor (C3aR) and C5a receptor). Mice that are… CONTINUE READING
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