Complement: A primer for the coming therapeutic revolution.

  title={Complement: A primer for the coming therapeutic revolution.},
  author={Scott Robert Barnum},
  journal={Pharmacology & therapeutics},
The complement system is an important part of the innate and adaptive immune systems. Originally characterized as a single serum component contributing to the killing of bacteria, we now know that there are close to sixty complement proteins, multiple activation pathways and a wide range of effector functions mediated by complement. The system plays a critical role in host defense against bacteria, viruses, fungi and other pathogens. However, inappropriate complement activation contributes to… CONTINUE READING