Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin.

  title={Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin.},
  author={Lan Lin and Yigal Paul Goldberg and Tomas Ganz},
  volume={106 8},
Mutations in a recently identified gene HJV (also called HFE2, or repulsive guidance molecule C, RgmC) are the major cause of juvenile hemochromatosis (JH). The protein product of HJV, hemojuvelin, contains a C-terminal glycosylphosphatidylinositol anchor, suggesting that it can be present in either a soluble or a cell-associated form. Patients with HJV hemochromatosis have low urinary levels of hepcidin, the principal iron-regulatory hormone secreted by the liver. However, neither the specific… CONTINUE READING
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