Competitive neuronal nicotinic receptor antagonists: a new direction for drug discovery.

@article{Dwoskin2001CompetitiveNN,
  title={Competitive neuronal nicotinic receptor antagonists: a new direction for drug discovery.},
  author={Linda P. Dwoskin and Peter A. Crooks},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2001},
  volume={298 2},
  pages={
          395-402
        }
}
Neuronal nicotinic acetylcholine receptors are distributed extensively throughout the central and peripheral nervous systems. Currently, there is great interest in determining the structural and functional diversity of these receptors, and in developing subtype-selective agonists that have potential as therapeutic agents for neuropathology and disease. However, relatively little attention has been focused on the development of subtype-selective nicotinic receptor antagonists. Such antagonists… CONTINUE READING

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