Competitive inhibition of renal tubular secretion of gemifloxacin by probenecid.

@article{Landersdorfer2009CompetitiveIO,
  title={Competitive inhibition of renal tubular secretion of gemifloxacin by probenecid.},
  author={Cornelia B. Landersdorfer and Charles M. Kirkpatrick and Martina Kinzig and Jurgen B. Bulitta and Ulrike Holzgrabe and George L. Drusano and Fritz Soergel},
  journal={Antimicrobial agents and chemotherapy},
  year={2009},
  volume={53 9},
  pages={
          3902-7
        }
}
Probenecid interacts with transport processes of drugs at several sites in the body. For most quinolones, renal clearance is reduced by concomitant administration of probenecid. The interaction between gemifloxacin and probenecid has not yet been studied. We studied the extent, time course, site(s), and mechanism of this interaction. Seventeen healthy volunteers participated in a randomized, two-way crossover study. Subjects received 320 mg gemifloxacin as an oral tablet without and with 4.5 g… CONTINUE READING

Figures, Tables, and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

First population pharmacokinetic analysis showing increased quinolone metabolite formation and clearance in patients with cystic fibrosis compared to healthy volunteers.

  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2018
VIEW 2 EXCERPTS
CITES METHODS

Effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in healthy Chinese volunteers

  • Drug design, development and therapy
  • 2016
VIEW 2 EXCERPTS
CITES METHODS & BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 35 REFERENCES

How well do gyrase

F. Sorgel, J. Bulitta, M. Kinzig-Schippers
  • LANDERSDORFER ET AL. ANTIMICROB. AGENTS CHEMOTHER. on O cber 22,
  • 2001
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Sheiner, and the NONMEM Project Group

S. L. Beal, L.B.A.J. Boeckmann
  • NONMEM users guides,
  • 1999
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL