Competitive inhibition of human skin collagenase by N-benzyloxycarbonyl-L-prolyl-L-alanyl-3-amino-2-oxopropyl-L-leucyl-L- alanylglycine ethyl ester.

Abstract

A 'ketomethylene' peptide, N-benzyloxycarbonyl-L-prolyl-L-alanyl-3-amino- 2-oxopropyl-L-leucyl-L-alanylglycine ethyl ester, was synthesized and shown to be a fairly potent competitive inhibitor of human skin collagenase.

Cite this paper

@article{Wallace1986CompetitiveIO, title={Competitive inhibition of human skin collagenase by N-benzyloxycarbonyl-L-prolyl-L-alanyl-3-amino-2-oxopropyl-L-leucyl-L- alanylglycine ethyl ester.}, author={Derek A. Wallace and Sandra R. Bates and Brian Walker and Graham Kay and Jeddin White and David J. S. Guthrie and N L Blumson and D T Elmore}, journal={The Biochemical journal}, year={1986}, volume={239 3}, pages={797-9} }