Competitive control of the self-renewing T cell repertoire.

@article{Boer1997CompetitiveCO,
  title={Competitive control of the self-renewing T cell repertoire.},
  author={Rob J de Boer and Alan S. Perelson},
  journal={International immunology},
  year={1997},
  volume={9 5},
  pages={779-90}
}
We develop a mathematical model for the self-renewing part of the T cell repertoire. Assuming that self-renewing T cells have to be stimulated by immunogenic MHC-peptide complexes presented on the surfaces of antigen-presenting cells, we derive a model of T cell growth in which competition for MHC-peptide complexes limits T cell clone sizes and regulates the total number of self-renewing T cells in the animal. We show that for a sufficient diversity and/or degree of cross-reactivity, the total… CONTINUE READING

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