Competitive cell interactions in cancer: a cellular tug of war.

  title={Competitive cell interactions in cancer: a cellular tug of war.},
  author={Laura J Wagstaff and Golnar Kolahgar and Eugenia Piddini},
  journal={Trends in cell biology},
  volume={23 4},
Within tissues, cells sense differences in fitness levels and this can lead to fitter cells eliminating less fit, albeit viable, cells via competitive cell interactions. The involvement of several cancer-related genes in this phenomenon has drawn attention to a potential connection between competitive cell interactions and cancer. Indeed, initial studies found that tumor-promoting genes can turn cells into 'supercompetitors', able to kill normal cells around them. However, more recently it has… CONTINUE READING
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