Competitive binding of alpha-actinin and calmodulin to the NMDA receptor.

  title={Competitive binding of alpha-actinin and calmodulin to the NMDA receptor.},
  author={Michael Wyszynski and Jerry Tsung-Kai Lin and Anuradha C K Rao and Elizabeth A. Nigh and Alan H. Beggs and Ann Marie Craig and Morgan Sheng},
  volume={385 6615},
The mechanisms by which neurotransmitter receptors are immobilized at postsynaptic sites in neurons are largely unknown. The activity of NMDA (N-methyl-D-aspartate) receptors is mechanosensitive and dependent on the integrity of actin, suggesting a functionally important interaction between NMDA receptors and the postsynaptic cytoskeleton. alpha-Actinin-2, a member of the spectrin/dystrophin family of actin-binding proteins, is identified here as a brain postsynaptic density protein that… CONTINUE READING
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