Competitive binding of Fe3+, Cr3+, and Ni2+ to transferrin

@article{Quarles2011CompetitiveBO,
  title={Competitive binding of Fe3+, Cr3+, and Ni2+ to transferrin},
  author={C. Derrick Quarles and R. Kenneth Marcus and Julia L. Brumaghim},
  journal={JBIC Journal of Biological Inorganic Chemistry},
  year={2011},
  volume={16},
  pages={913-921}
}
Competitive binding of Fe3+, Cr3+, and Ni2+ to transferrin (Tf) was investigated at various physiological iron to Tf concentration ratios. Loading percentages for these metal ions are based on a two Mn+ to one Tf (i.e., 100% loading) stoichiometry and were determined using a particle beam/hollow cathode–optical emission spectroscopy (PB/HC-OES) method. Serum iron concentrations typically found in normal, iron-deficient, iron-deficient from chronic disease, iron-deficient from inflammation, and… 
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