Competitive and non-competitive regulation of calcium-dependent inactivation in CaV1.2 L-type Ca2+ channels by calmodulin and Ca2+-binding protein 1.

@article{Oz2013CompetitiveAN,
  title={Competitive and non-competitive regulation of calcium-dependent inactivation in CaV1.2 L-type Ca2+ channels by calmodulin and Ca2+-binding protein 1.},
  author={Shimrit Oz and Adva Benmocha and Yehezkel Sasson and Dana Sachyani and L. Almagor and Amy Lee and Joel Alan Hirsch and Nathan Dascal},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 18},
  pages={12680-91}
}
CaV1.2 interacts with the Ca(2+) sensor proteins, calmodulin (CaM) and calcium-binding protein 1 (CaBP1), via multiple, partially overlapping sites in the main subunit of CaV1.2, α1C. Ca(2+)/CaM mediates a negative feedback regulation of Cav1.2 by incoming Ca(2+) ions (Ca(2+)-dependent inactivation (CDI)). CaBP1 eliminates this action of CaM through a… CONTINUE READING