Competitive Kinase Enrichment Proteomics Reveals that Abemaciclib Inhibits GSK3β and Activates WNT Signaling.

Abstract

The cellular and organismal phenotypic response to a small-molecule kinase inhibitor is defined collectively by the inhibitor's targets and their functions. The selectivity of small-molecule kinase inhibitors is commonly determined in vitro, using purified kinases and substrates. Recently, competitive chemical proteomics has emerged as a complementary… (More)
DOI: 10.1158/1541-7786.MCR-17-0468

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Cite this paper

@article{Cousins2017CompetitiveKE, title={Competitive Kinase Enrichment Proteomics Reveals that Abemaciclib Inhibits GSK3β and Activates WNT Signaling.}, author={Emily M Cousins and Dennis Goldfarb and Feng Yan and Jose R Roques and David Brian Darr and Gary Leon Johnson and Michael B. Major}, journal={Molecular cancer research : MCR}, year={2017} }