Competitive Calcium Binding: Implications for Dendritic Calcium Signaling

  title={Competitive Calcium Binding: Implications for Dendritic Calcium Signaling},
  author={Henry Markram and Arnd Roth and Fritjof Helmchen},
  journal={Journal of Computational Neuroscience},
Action potentials evoke calcium transients in dendrites of neocortical pyramidal neurons with time constants of <100 ms at physiological temperature. This time period may not be sufficient for inflowing calcium ions to equilibrate with all present Ca2+-binding molecules. We therefore explored nonequilibrium dynamics of Ca2+ binding to numerous Ca2+ reaction partners within a dendritelike compartment using numerical simulations. After a brief Ca2+ influx, the reaction partner with the fastest… CONTINUE READING