Competitive 7 V-Methyl-D-Aspartate Receptor Blockade Reduces Brain Injury Following Transient Focal Ischemia in Cats

Background and Purpose We tested the hypothesis that administration of the competitive N-methyl-D-aspartate (NMDA) receptor antagonist NPC 17742 (2R,4R,5S-[2-amino-4,5-(l,2-cyclohexyl)-7-phosphonoheptanoic acid]) during transient focal ischemia affects early postischemic brain injury. Methods Halothane-anesthetized cats underwent 1 hour of left middle… (More)

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