Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate.

@article{Iakova2004CompetitionOC,
  title={Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate.},
  author={Polina A Iakova and Guo-li Wang and Lubov Timchenko and Marek Michalak and Olivia M. Pereira-Smith and James R. Smith and Nikolai A. Timchenko},
  journal={The EMBO journal},
  year={2004},
  volume={23 2},
  pages={406-17}
}
Induction of p21 in senescent human fibroblasts plays a key role in the inactivation of cyclin-dependent kinases and the resulting irreversible growth arrest in the early stages of cell senescence. We found that RNA-binding proteins are critical regulators of p21 during senescence. Two RNA-binding proteins, CUGBP1 and calreticulin (CRT), interact with the same nucleotide sequences within the 5' region of p21 mRNA, but have opposite effects on the translation of p21 mRNA. CUGBP1 increases… CONTINUE READING