Competition in vivo between a cytopathic variant and a wild-type duck hepatitis B virus.

@article{Lenhoff1998CompetitionIV,
  title={Competition in vivo between a cytopathic variant and a wild-type duck hepatitis B virus.},
  author={R J Lenhoff and Carolyn A Luscombe and Jesse Summers},
  journal={Virology},
  year={1998},
  volume={251 1},
  pages={85-95}
}
Several examples of human hepatitis B virus strains with enhanced replication in vitro have been described. To understand whether this characteristic could be a cause of liver disease, we have studied a variant of the closely related duck hepatitis B virus (DHBV) that had enhanced levels of cccDNA accumulation, previously shown to be cytopathic in vitro, as a model for the pathogenesis of analogous viruses in humans. In vivo liver damage caused by this variant (G133E) occurred only during the… CONTINUE READING