Competition for catalytic resources alters biological network dynamics.

  title={Competition for catalytic resources alters biological network dynamics.},
  author={Yannick Rondelez},
  journal={Physical review letters},
  volume={108 1},
Genetic regulation networks orchestrate many complex cellular behaviors. Dynamic operations that take place within cells are thus dependent on the gene expression machinery, enabled by powerful enzymes such as polymerases, ribosomes, or nucleases. These generalist enzymes typically process many different substrates, potentially leading to competitive situations: by saturating the common enzyme, one substrate may down-regulate its competitors. However, most theoretical or experimental models… CONTINUE READING
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