Competition for antigen determines the stability of T cell-dendritic cell interactions during clonal expansion.

@article{Garcia2007CompetitionFA,
  title={Competition for antigen determines the stability of T cell-dendritic cell interactions during clonal expansion.},
  author={Zacarias Garcia and Emmanuelle Pradelli and Susanna Celli and H{\'e}l{\`e}ne Beuneu and Aur{\'e}lie Simon and Philippe Bousso},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 11},
  pages={4553-8}
}
The regulation of T cell-dendritic cell (DC) contacts during clonal expansion is poorly defined. Although optimal CD4 T cell responses require prolonged exposure to antigen (Ag), it is believed that stable T cell-DC interactions occur only during the first day of the activation process. Here we show that recently activated CD4 T cells are in fact fully competent for establishing contact with Ag-bearing DC. Using two-photon imaging, we found that whereas prolonged interactions between activated… CONTINUE READING