Competition favouring inactive over active motor neurons during synapse elimination

@article{Callaway1987CompetitionFI,
  title={Competition favouring inactive over active motor neurons during synapse elimination},
  author={Edward M. Callaway and James M. Soha and David C. Van Essen},
  journal={Nature},
  year={1987},
  volume={328},
  pages={422-426}
}
During normal postnatal maturation, mammalian muscles undergo an orderly process of synapse elimination, whereby each muscle fibre loses all but one of the multiple inputs with which it is endowed at birth1. Experimental perturbations that increase or decrease the overall activity of nerve and/or muscle cause a corresponding increase or decrease in the overall rate of neuromuscular synapse elimination2–7. On other grounds it has been suggested that competition among motor neurons is important… CONTINUE READING

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