Competition between two enzymes for substrate removal in liver: Modulating effects due to substrate recruitment of hepatocyte activity

Abstract

Modulating effects of competing pathways, exemplified by sulfation (high affinity-low capacity) and glucuronidation (low affinity-high capacity), on drug disappearance and metabolite formation were investigated in a simulation study. The phenomenon of substrate recruitment of hepatocyte activity in drug removal and metabolite formation was shown with… (More)
DOI: 10.1007/BF01061758

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