Competition between noggin and bone morphogenetic protein 4 activities may regulate dorsalization during Xenopus development.

@article{ReemKalma1995CompetitionBN,
  title={Competition between noggin and bone morphogenetic protein 4 activities may regulate dorsalization during Xenopus development.},
  author={Y Re'em-Kalma and Thomas W. Lamb and Dale Frank},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 26},
  pages={
          12141-5
        }
}
Bone morphogenetic protein 4 (BMP-4) induces ventral mesoderm but represses dorsal mesoderm formation in Xenopus embryos. We show that BMP-4 inhibits two signaling pathways regulating dorsal mesoderm formation, the induction of dorsal mesoderm (Spemann organizer) and the dorsalization of ventral mesoderm. Ectopic expression of BMP-4 RNA reduces goosecoid and forkhead-1 transcription in whole embryos and in activin-treated animal cap explants. Embryos and animal caps overexpressing BMP-4… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 10 CITATIONS

Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice.

  • The Journal of clinical investigation
  • 2003
VIEW 14 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

A Meis family protein caudalizes neural cell fates in Xenopus

  • Mechanisms of Development
  • 1999
VIEW 4 EXCERPTS
CITES BACKGROUND & METHODS

Dissecting hematopoietic differentiation using the embryonic stem cell differentiation model.

  • The International journal of developmental biology
  • 2010
VIEW 1 EXCERPT
CITES RESULTS

Spemann organizer activity of Smad10.

VIEW 1 EXCERPT
CITES BACKGROUND