Competition between 11C-raclopride and endogenous dopamine in Parkinson's disease.

@article{Ishibashi2010CompetitionB1,
  title={Competition between 11C-raclopride and endogenous dopamine in Parkinson's disease.},
  author={Kenji Ishibashi and Kenji Ishii and Keiichi Oda and Hidehiro Mizusawa and Kiichi Ishiwata},
  journal={Nuclear medicine communications},
  year={2010},
  volume={31 2},
  pages={159-66}
}
OBJECTIVE The aim of this study was to understand whether the increase in 11C-raclopride binding in the striatum of patients with Parkinson's disease (PD) is associated with the depletion of endogenous dopamine. METHODS Positron emission tomography (PET) scans of the two dopamine D2 receptor ligands, 11C-raclopride and 11C-N-methylspiperone (11C-NMSP), and the dopamine transporter ligand, 11C-2beta-carbomethoxy-3beta-(4-fluorophenyl)-tropane, were performed on five patients with PD and seven… CONTINUE READING
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