Competition Studies Confirm Two Major Barriers That Can Preclude the Spread of Resistance to Quorum-Sensing Inhibitors in Bacteria

@inproceedings{Gerdt2014CompetitionSC,
  title={Competition Studies Confirm Two Major Barriers That
Can Preclude the Spread of Resistance to Quorum-Sensing Inhibitors
in Bacteria},
  author={Joseph P. Gerdt and Helen E Blackwell},
  booktitle={ACS chemical biology},
  year={2014}
}
The growing threat of antibiotic resistance necessitates the development of novel antimicrobial therapies. Antivirulence agents that target group-beneficial traits in microorganisms (i.e., phenotypes that help the cells surrounding the producer cell instead of selfishly benefiting only the producer cell) represent a new antimicrobial approach that may be robust against the spread of resistant mutants. One prominent group-beneficial antivirulence target in bacteria is quorum sensing (QS). While… CONTINUE READING
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