Competing fragmentation processes in tandem mass spectra of heparin-like glycosaminoglycans.

  title={Competing fragmentation processes in tandem mass spectra of heparin-like glycosaminoglycans.},
  author={Estee F Naggar and Catherine E. Costello and Joseph Zaia},
  journal={Journal of the American Society for Mass Spectrometry},
  volume={15 11},
Heparin-like glycosaminoglycans (HLGAGs) are highly sulfated, linear carbohydrates attached to proteoglycan core proteins and expressed on cell surfaces and in basement membranes. These carbohydrates bind several families of growth factors and growth factor receptors and act as coreceptors for these molecules. Tandem mass spectrometry has the potential to increase our understanding of the biological significance of HLGAG expression by providing a facile means for sequencing these molecules… CONTINUE READING

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