Competing designs for drug combination in phase I dose-finding clinical trials.

  title={Competing designs for drug combination in phase I dose-finding clinical trials.},
  author={M-K Riviere and Fanny Dubois and Sarah Zohar},
  journal={Statistics in medicine},
  volume={34 1},
The aim of phase I combination dose-finding studies in oncology is to estimate one or several maximum tolerated doses (MTDs) from a set of available dose levels of two or more agents. Combining several agents can indeed increase the overall anti-tumor action but at the same time also increase the toxicity. It is, however, unreasonable to assume the same dose-toxicity relationship for the combination as for the simple addition of each single agent because of a potential antagonist or synergistic… CONTINUE READING
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