Competing crossover pathways act during meiosis in Saccharomyces cerevisiae.

@article{Argueso2004CompetingCP,
  title={Competing crossover pathways act during meiosis in Saccharomyces cerevisiae.},
  author={Juan Lucas Argueso and Jennifer J Wanat and Zekeriyya Gemici and Eric Alani},
  journal={Genetics},
  year={2004},
  volume={168 4},
  pages={1805-16}
}
In Saccharomyces cerevisiae the MSH4-MSH5, MLH1-MLH3, and MUS81-MMS4 complexes act to promote crossing over during meiosis. MSH4-MSH5, but not MUS81-MMS4, promotes crossovers that display interference. A role for MLH1-MLH3 in crossover control is less clear partly because mlh1Delta mutants retain crossover interference yet display a decrease in crossing over that is only slightly less severe than that seen in msh4Delta and msh5Delta mutants. We analyzed the effects of msh5Delta, mlh1Delta, and… CONTINUE READING

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