Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N'-nitro-N-nitrosoguanidine.

@article{Carethers1996CompetencyIM,
  title={Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N'-nitro-N-nitrosoguanidine.},
  author={John M. Carethers and M T Hawn and Dharam P. Chauhan and Michael C. Luce and Giancarlo Marra and Minoru Koi and Clement Richard Boland},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={98 1},
  pages={199-206}
}
The phenomenon of alkylation tolerance has been observed in cells that are deficient in some component of the DNA mismatch repair (MMR) system. An alkylation-induced cell cycle arrest had been reported previously in one MMR-proficient cell line, whereas a MMR-defective clone derived from this line escapes from this arrest. We examined human cancer cell lines to determine if the cell cycle arrest were dependent upon the MMR system. Growth characteristics and cell cycle analysis after MNNG… CONTINUE READING

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