Competence to undergo normal, fertilization-induced cortical activation develops after metaphase I of meiosis in mouse oocytes.

@article{Ducibella1994CompetenceTU,
  title={Competence to undergo normal, fertilization-induced cortical activation develops after metaphase I of meiosis in mouse oocytes.},
  author={Tom Ducibella and J Buetow},
  journal={Developmental biology},
  year={1994},
  volume={165 1},
  pages={95-104}
}
The purpose of this study was to determine at what stage of meiotic maturation mouse oocytes develop the ability to undergo sperm-induced activation, assayed by cortical granule (CG) release. Germinal vesicle breakdown (GVBD), prometaphase I (proMI), metaphase I (MI), and metaphase II (MII, the normal stage at fertilization) stages were evaluated by quantitative image analysis. At 2 hr, fertilized MII eggs underwent a mean CG loss of 69%; loss was global--in the entire cortex occupied by CGs… CONTINUE READING

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