Competence and competition: the challenge of becoming a long-lived plasma cell

@article{Radbruch2006CompetenceAC,
  title={Competence and competition: the challenge of becoming a long-lived plasma cell},
  author={Andreas Radbruch and Gwendolin Muehlinghaus and Elke O Luger and Ayako Inamine and Kenneth G. C. Smith and Thomas D{\"o}rner and Falk Hiepe},
  journal={Nature Reviews Immunology},
  year={2006},
  volume={6},
  pages={741-750}
}
Plasma cells provide humoral immunity. They have traditionally been viewed mainly as short-lived end-stage products of B-cell differentiation that deserve little interest. This view is changing, however, because we now know that plasma cells can survive for long periods in the appropriate survival niches and that they are an independent cellular component of immunological memory. Studies of the biology of plasma cells reveal a mechanism of intriguing simplicity and elegance that focuses memory… 
Plasma cell development and survival
Summary:  Plasma cells have long been recognized as the basis of humoral immunity, yet we are only now beginning to appreciate the complexities of plasma cell development and the fact that not all
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  • Biology, Medicine
    Nature Reviews Immunology
  • 2007
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A model in which the production of low-affinity antibody shortly after antigenic challenge leads to the formation of immune complexes that can crosslink FcγRIIb on bone-marrow plasma cells, leading to the death of a small number of such cells is supported.
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Long-Lived Plasma Cells
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