Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis.

  title={Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis.},
  author={Huajing Wan and Sharon Dingle and Yan M. Xu and Val{\'e}rie Besnard and Klaus H. Kaestner and S Ang and Susan E. Wert and Mildred T. Stahlman and Jeffrey A. Whitsett},
  journal={The Journal of biological chemistry},
  volume={280 14},
Foxa1 and Foxa2 are closely related family members of the Foxa group of transcription factors that are coexpressed in subsets of respiratory epithelial cells throughout lung morphogenesis. Shared patterns of expression, conservation of DNA binding, and transcriptional activation domains indicate that they may serve complementary functions in the regulation of gene expression during lung morphogenesis. Whereas branching morphogenesis of the fetal lung occurs normally in the Foxa2Delta/Delta and… CONTINUE READING