Compensatory phosphorylation of isocitrate dehydrogenase. A mechanism for adaptation to the intracellular environment.

@article{Laporte1985CompensatoryPO,
  title={Compensatory phosphorylation of isocitrate dehydrogenase. A mechanism for adaptation to the intracellular environment.},
  author={D C Laporte and P E Thorsness and Daniel E. Koshland},
  journal={The Journal of biological chemistry},
  year={1985},
  volume={260 19},
  pages={10563-8}
}
When Escherichia coli grows on acetate, the flow of isocitrate through the glyoxylate bypass is regulated, in part, through the phosphorylation of isocitrate dehydrogenase. In addition to its role in adaptation to alternative carbon sources, this phosphorylation system responds to variation in the intracellular level of isocitrate dehydrogenase. This system can compensate for changes in the cellular level of isocitrate dehydrogenase in excess of 10-fold, maintaining a nearly constant activity… CONTINUE READING
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