Compensatory phospholipid digestion is required for cholesterol absorption in pancreatic phospholipase A(2)-deficient mice.

@article{Richmond2001CompensatoryPD,
  title={Compensatory phospholipid digestion is required for cholesterol absorption in pancreatic phospholipase A(2)-deficient mice.},
  author={Bonnie Richmond and Amy C Boileau and Shuqin Zheng and Kyle Huggins and Norman A. Granholm and Patrick Tso and David Y Hui},
  journal={Gastroenterology},
  year={2001},
  volume={120 5},
  pages={1193-202}
}
BACKGROUND AND AIMS Numerous studies have suggested phospholipid inhibition of dietary cholesterol absorption through the gastrointestinal tract. This study addressed the importance of luminal phospholipid hydrolysis in this process. METHODS The effect of phospholipase inhibition on cholesterol transport from intestinal lumen to the lymphatics was evaluated in lymph fistula rats. Cholesterol and phospholipid absorption efficiency in intact animals was evaluated in control and phospholipase A… CONTINUE READING

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