Compensatory mutations rescue the virus replicative capacity of VIRIP-resistant HIV-1.


VIRIP has been identified as a highly specific natural inhibitor of HIV-1 that blocks HIV-1 gp41-dependent fusion by interacting with the gp41 fusion peptide. Two analogues of VIRIP (VIR-353 and VIR-576) with a few amino acid changes increase its antiretroviral potency by two orders of magnitude in cell culture. VIR-576 has been shown effective in a phase I… (More)
DOI: 10.1016/j.antiviral.2011.10.010


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