Compensatory mechanisms in degenerative neurologic diseases. Insights from parkinsonism.

@article{Calne1991CompensatoryMI,
  title={Compensatory mechanisms in degenerative neurologic diseases. Insights from parkinsonism.},
  author={D. B. Calne and Michael J. Zigmond},
  journal={Archives of neurology},
  year={1991},
  volume={48 4},
  pages={
          361-3
        }
}
In animal models of parkinsonism, the ability to lose a substantial proportion of dopaminergic neurons without behavioral deficits does not derive from other systems taking over function of the dopaminergic pathway. The surviving nigrostriatal projection increases both the rate of synthesis and the release of dopamine, as compensatory adjustments. This capacity allows at least a fivefold rise in dopamine delivery per neuron, and this enhancement is potentiated further by receptor up-regulation… CONTINUE READING

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